N-acetoacetylaspartic acid → N-acetoacetyl-L-aspartic anhydride

HRID 1633382Notes

Reaction equation

HRID 1633382 reaction equation
[C:1]([NH:7][C@H:8]([C:13]([OH:15])=[O:14])[CH2:9][C:10]([OH:12])=O)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]>C(O)(=O)C.C(OC(=O)C)(=O)C>[C:1]([NH:7][C@@H:8]1[C:13](=[O:14])[O:15][C:10](=[O:12])[CH2:9]1)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]

Participants

4

Reactant 1

HCID 13334672N-acetoacetylaspartic acid

Product 1

HCID 13334674N-acetoacetyl-L-aspartic anhydride

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 7918Acetic AnhydrideSolvent

Procedure

1.41 parts of N-acetoacetyl-L-aspartic acid were dissolved in 25 parts by volume of acetic acid, and 5 parts by volume of acetic anhydride were added and the mixture was stirred overnight under nitrogen. Solvent was removed under vacuum at 40°-45° C. 50 parts by volume of acetic acid were added and the evaporation repeated to form N-acetoacetyl-L-aspartic anhydride.

Workup

  1. additionwere added
  2. customSolvent was removed under vacuum at 40°-45° C
  3. addition50 parts by volume of acetic acid were added
  4. customthe evaporation

Sources & evidence

ORD record
ord-00d8e08264bc46b4a707a8ab2456d590
Source dataset
uspto-grants-1984_10
Patent number
US04480112

Reaction notes

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