HCID 11263812, compound → HCID 11286800, compound

HRID 1633404Notes

Reaction equation

HRID 1633404 reaction equation
[CH3:1][C:2]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)([OH:4])[CH3:3].[H][H]>[C].[Pd].C(O)C>[CH3:3][C:2]([CH:5]1[CH2:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[O:6]1)([OH:4])[CH3:1]

Participants

5

Reactant 2

HCID 11263812HCID 11263812, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 11286800HCID 11286800, compoundYield 65.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Into 200 ml of ethanol, was dissolved 10.3 g of 2-(1-methyl-1-hydroxyethyl)benzofuran. To the solution, was added 1.1 g of 10% palladium carbon. Hydrogen was introduced into the mixture with shaking at atmospheric pressure and at room temperature until no more hydrogen had been absorbed (it took 6 hours). The reaction mixture was filtered and the filtrate was concentrated in vacuo. The residue was distilled under reduced pressure to obtain 6.86 g of the intended product boiling at 78°-95° C./0.4 mmHg.

Workup

  1. customhad been absorbed (it took 6 hours)
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated in vacuo
  4. distillationThe residue was distilled under reduced pressure

Sources & evidence

ORD record
ord-3f046c566e974daab392b256cb92f090
Source dataset
uspto-grants-1984_10
Patent number
US04480118

Reaction notes

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