HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isatoic Anhydride → (3S)-3-Methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isatoic Anhydride | HCID 8359 | — |
| Reactant | D-Alanine | HCID 71080 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | (3S)-3-Methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione | HCID 12282507 | 20.7% |
Reaction Steps
Following the procedure of Example 5, D-alanine (73.6 mmol) and isatoic anhydride (61.3 mmol) were allowed to reflux in pyridine (50 mL) to give (3R)-3-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (12.7 mmol) as a light brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503900B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-a26ac89d636d4042a856f006ad0e83e6 |
| Source note | uspto-grants-2003_01 |