(3S)-3-Methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione → HCID 69299933, compound

HRID 1633507Notes

Reaction equation

HRID 1633507 reaction equation
[CH3:1][C@H:2]1[NH:8][C:7](=O)[C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[NH:4][C:3]1=O>B.C1COCC1>[CH3:1][C@H:2]1[NH:8][CH2:7][C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[NH:4][CH2:3]1

Participants

3

Reactant 1

HCID 12282507(3S)-3-Methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione

Product 1

HCID 69299933HCID 69299933, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 2723981Borane;tetrahydrofuranSolvent

Procedure

(3R)-3-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (12.7 mmol) was allowed to react with 60 mL 1M BH3/THF to give (3R)-3-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine as a white foam/clear oil (8.6 mmol).

Sources & evidence

ORD record
ord-b81914a53655405b8dbcb6dfad03614d
Source dataset
uspto-grants-2003_01
Patent number
US06503900B2

Reaction notes

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