Benzophenone imine → N-[(3-chloro-5-trifluoromethyl-2-pyridyl)methyl]benzophenone Imine

HRID 1633555Notes

Reaction equation

HRID 1633555 reaction equation
[C:1](=[NH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[Cl:16][C:17]1[C:18]([CH2:27]N)=[N:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1>ClCCl>[Cl:16][C:17]1[C:18]([CH2:27][N:14]=[C:1]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:19][CH:20]=[C:21]([C:23]([F:25])([F:24])[F:26])[CH:22]=1

Participants

4

Reactant 2

HCID 136809Benzophenone imineHCID 114997441-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]methanamine hydrochloride

Product 1

HCID 22629928N-[(3-chloro-5-trifluoromethyl-2-pyridyl)methyl]benzophenone Imine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of benzophenone imine (1.67 ml) in dry dichloromethane (25 ml) at 10° C. was added (3-chloro-5-trifluoromethyl-2-pyridyl)methylamine hydrochloride (2.47 g). The solution was stirred at room temperature for 3 hours and then filtered. The filtrate was evaporated to dryness and purified by silica gel chromatography [light petroleumidiethyl ether (4:1)] to give the title product.

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness
  3. custompurified by silica gel chromatography [light petroleumidiethyl ether (4:1)]

Sources & evidence

ORD record
ord-a12a2f0e78164af393869f578c9198b9
Source dataset
uspto-grants-2003_01
Patent number
US06503933B1

Reaction notes

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