Water → HCID 18679841, compound

HRID 1633565Notes

Reaction equation

HRID 1633565 reaction equation
[CH2:1]([NH:5][CH3:6])[CH2:2][CH2:3][CH3:4].[Br:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19].O>C(Cl)Cl>[Br:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][S:18](=[O:20])(=[O:19])[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH3:6]

Participants

5

Reactant 3

HCID 962WaterHCID 8068N-MethylbutylamineHCID 1867984510-Bromodecanesulfonyl chloride

Product 1

HCID 18679841HCID 18679841, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

9.63 mmol of n-butylmethylamine is dissolved in 6 ml of absolute CH2Cl2. In a moisture-free environment, 1.85 mmol of 1-bromo-10-decanesulfonyl chloride is now slowly added in drops to 2.5 ml of CH2Cl2 while being cooled with ice. Then, it is stirred for another five hours at room temperature. The mixture is mixed with 10 ml of water, stirred thoroughly for a short time and the organic phase is separated. The aqueous phase is extracted with ether, and the combined organic phases are then washed with saturated NaCl solution and water. After drying on MgSO4, the solvent is removed in a rotary evaporator.

Workup

  1. temperaturewhile being cooled with ice
  2. stirringstirred thoroughly for a short time
  3. customthe organic phase is separated
  4. extractionThe aqueous phase is extracted with ether
  5. washthe combined organic phases are then washed with saturated NaCl solution and water
  6. customAfter drying on MgSO4
  7. customthe solvent is removed in a rotary evaporator

Sources & evidence

ORD record
ord-ab4e150a234041d387c989faa98b0ac4
Source dataset
uspto-grants-2003_01
Patent number
US06503938B1

Reaction notes

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