Hydrochloric Acid → HCID 18679819, compound

Participants

Reaction Steps

66.7 g (0.3 mol) of 3-(3-tert-butyl-4-hydroxy-phenyl)-propionic acid (prepared analogously to the method described in JP-A2-63/227542) in 58 g (0.4 mol) of aqueous glyoxal solution (40% by weight) and 3 ml of hydrochloric acid (32% by weight) are heated at reflux in 200 ml of acetic acid for 6 hours. The mixture is then poured into 600 ml of ice-water and the precipitate is filtered off. The filter residue is washed with water and then dried at 60° C. g. Recrystallisation from toluene results in 54.3 g (69% of theory) of 3-(7-tert-butyl-2-oxo-2,3-dihydro-benzofuran-5-yl)-propionic acid. Melting point 167-169° C.

Provenance & Evidence