HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1633618Generated: October 27, 2026
Potassium Carbonate → 5-(7-Bromo-heptyloxy)-1-(4-fluoro-phenyl)-1H-indole
https://huagongshe.com/reaction/1633618
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,7-Dibromoheptane | HCID 78309 | — |
| Reactant | 1-(4-Fluoro-phenyl)-1H-indol-5-ol | HCID 11481556 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 5-(7-Bromo-heptyloxy)-1-(4-fluoro-phenyl)-1H-indole | HCID 18679556 | 72.3% |
Reaction Steps
410 mg (1.8 mmol) 1-(4-Fluoro-phenyl)-1H-indol-5-ol in 6 ml acetone were treated with 500 mg (3.6 mmol) powdered K2CO3 and 610 μl (3.6 mmol) 1,7-dibromoheptane. The suspension was stirred at 60° C. overnight, cooled to RT, filtered and concentrated. Column chromatography on silica gel with hexane/EtOAc 49:1 yielded 526 mg (72%) 5-(7-Bromo-heptyloxy)-1-(4-fluoro-phenyl)-1H-indole as colorless solid, mp 63-65° C., MS: 403 (M, 1Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06503907B2 |
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| Source dataset | uspto-grants-2003_01 |
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| ORD ID | ord-fc27129c678f421dae5a9b7790a56f76 |
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| Source note | uspto-grants-2003_01 |
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