1-Bromo-2-fluorobenzene → {4-[1-(2-Bromo-phenyl)-1H-indol-5-yloxy]-butyl}-diethyl-amine

HRID 1633630Notes

Reaction equation

HRID 1633630 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[CH:12]2)[CH3:2].[Br:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1F>>[Br:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:14]1[C:15]2[C:11](=[CH:10][C:9]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:18][CH3:19])=[CH:17][CH:16]=2)[CH:12]=[CH:13]1

Participants

3

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 18679455Diethyl-[4-(1H-indol-5-yloxy)-butyl]-amine

Product 1

HCID 18679502{4-[1-(2-Bromo-phenyl)-1H-indol-5-yloxy]-butyl}-diethyl-amine

Procedure

In analogy to example 4.6, Diethyl-[4-(1H-indol-5-yloxy)-butyl]-amine and 1-bromo-2-fluoro-benzene were converted to yield {4-[1-(2-Bromo-phenyl)-1H-indol-5-yloxy]-butyl}-diethyl-amine as light yellow oil, MS: 415 (MH+, 1Br).

Sources & evidence

ORD record
ord-b28393052dea4b0ead9f3979279f2bbf
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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