HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol → 5-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-pentan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol | HCID 18679522 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-pentan-1-ol | HCID 18679448 | 79.3% |
Reaction Steps
400 mg (1.4 mmol) 5-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol in 10 ml EtOH were hydrogenated in the presence of 25 Mg PtO2. The suspension was filtered and the crude material purified by column chromatography on silica gel with hexane/EtOAc to yield 330 mg (79%) 5-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-pentan-1-ol as colorless viscous oil, MS: 297 (M).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503907B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-106035f3745d4789bb6cec30a9bd2748 |
| Source note | uspto-grants-2003_01 |