HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-prop-2-yn-1-ol → 3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-prop-2-yn-1-ol | HCID 18679472 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-propan-1-ol | HCID 18679458 | 87.9% |
Reaction Steps
800 mg (3 mmol) 3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-prop-2-yn-1-ol in 25 ml MeOH were hydrogenated in the presence of 100 mg PtO2, filtered and evaporated to yield 710 mg crude 3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-propan-1-ol as colorless gum, MS: 270 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503907B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-fc46f4f6032048058bf467dc66dfc3eb |
| Source note | uspto-grants-2003_01 |