Triethylamine → Methanesulfonic acid 5-[1-(4-fluoro-phenyl)-1H-indol-5-yl]-pentyl ester

Participants

Reaction Steps

300 mg (1 mmol) 5-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-pentan-1-ol in 10 ml CH2Cl2 were treated with 0.1 ml (1.2 mmol) methane sulfonyl chloride and 0.41 ml (3 mmol) triethyl amine at 0° C. The solution was stirred at RT for 2 h, was diluted with CH2Cl2 and extracted with 1M HCl and water, and dried over Na2SO4. Evaporation yielded 310 mg (83%) Methanesulfonic acid 5-[1-(4-fluoro-phenyl)-1H-indol-5-yl]-pentyl ester as light brown oil, MS: 376 (MH+).

Provenance & Evidence