反应详情

温度

60 °C

To 1.3 g (3.5 mmol) 5-[5-(Allyl-methyl-amino)-pentyl]-indole-1-carboxylic acid tert-butyl ester in 20 ml ethanol were added 1.5 ml water and 3 ml conc. NaOH, and stirred at 60° C. for 1.5 h. The slurry was concentrated and dissolved in ether/water. The organic layer was washed with water and dried over Na2SO4 and evaporated to yield 900 mg (quantitative) Allyl-[5-(1H-indol-5-yl)-pentyl]-methyl-amine as light yellow oil, MS: 257 (MH+).

1. concentrationThe slurry was concentrated
2. dissolutiondissolved in ether/water
3. washThe organic layer was washed with water
4. dry with materialdried over Na2SO4
5. customevaporated