1-Bromo-3-fluorobenzene → Allyl-{5-[1-(3-bromo-phenyl)-1H-indol-5-yl]-pentyl}-methyl-amine

HRID 1633648Notes

Reaction equation

HRID 1633648 reaction equation
[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH:15]=[CH:14]2)[CH3:5])[CH:2]=[CH2:3].[Br:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23](F)[CH:22]=1>>[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[N:16]([C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([Br:20])[CH:22]=1)[CH:15]=[CH:14]2)[CH3:5])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 140821-Bromo-3-fluorobenzeneHCID 18679431Allyl-[5-(1H-indol-5-yl)-pentyl]-methyl-amine

Product 1

HCID 18679554Allyl-{5-[1-(3-bromo-phenyl)-1H-indol-5-yl]-pentyl}-methyl-amine

Procedure

In analogy to example 4.6, Allyl-[5-(1H-indol-5-yl)-pentyl]-methyl-amine and 1-bromo-3-fluoro-benzene were converted to yield Allyl-{5-[1-(3-bromo-phenyl)-1H-indol-5-yl]-pentyl}-methyl-amine as light brown oil, MS: 411 (MH+, 1Br).

Sources & evidence

ORD record
ord-c0ccb0fdc5454b569f82cf982cef10a5
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

Loading…