2-Fluorobiphenyl → Allyl-[5-(1-biphenyl-2-yl-1H-indol-5-yl)-pentyl]-methyl-amine

HRID 1633649Notes

Reaction equation

[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH:15]=[CH:14]2)[CH3:5])[CH:2]=[CH2:3].F[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[N:16]([C:32]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:22]1[CH:21]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH:15]=[CH:14]2)[CH3:5])[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 675792-Fluorobiphenyl

HCID 18679431Allyl-[5-(1H-indol-5-yl)-pentyl]-methyl-amine

Product 1

HCID 18679524Allyl-[5-(1-biphenyl-2-yl-1H-indol-5-yl)-pentyl]-methyl-amine

Procedure

In analogy to example 4.6, Allyl-[5-(1H-indol-5-yl)-pentyl]-methyl-amine and 2-fluoro-biphenyl were converted to yield Allyl-[5-(1-biphenyl-2-yl-1H-indol-5-yl)-pentyl]-methyl-amine as light yellow oil, MS: 409 (MH+).

Sources & evidence

ORD record: ord-cd25f6164334485799abf189e95ce40f
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06503907B2

Reaction notes

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