Lithium tri-s-butylborohydride → HCID 18679504, compound

Participants

Reaction Conditions

Reaction Steps

To 140 ml (140 mmol) 1M L-selectride in THF (Lithium-tri-sec-butylborohydride), 14.9 g (50 mmol) 1-(4-Bromo-phenyl)-5-methoxy-1H-indole were added slowly in small portions at RT. The mixture was stirred at 75° C. for 60 h, concentrated and dissolved in ether and water. The organic phase was washed with water and dried over Na2SO4. Trituration with cyclohexane yielded 13.9 g (96%) 1-(4-Bromo-phenyl)-1H-indol-5-ol as grey solid, MS: 287 (MH+).

Provenance & Evidence