HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Ethyl-{5-[1-(4-ethynyl-phenyl)-1H-indol-5-yl]-pent-4-ynyl}-amino)-ethanol → 2-(Ethyl-{5-[1-(4-ethyl-phenyl)-1H-indol-5-yl]-pentyl}-amino)-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Ethyl-{5-[1-(4-ethynyl-phenyl)-1H-indol-5-yl]-pent-4-ynyl}-amino)-ethanol | HCID 18679467 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Ethyl-{5-[1-(4-ethyl-phenyl)-1H-indol-5-yl]-pentyl}-amino)-ethanol | HCID 18679466 | 13.2% |
Reaction Steps
60 mg (0.16 mmol) 2-(Ethyl-{5-[1-(4-ethynyl-phenyl)-1H-indol-5-yl]-pent-4-ynyl}-amino)-ethanol in 10 ml MeOH were hydrogenated in the presence of 20 mg Pd/C, filtered and concentrated. Purification by column chromatography on silica gel with CH2Cl2/MeOH 9:1 yielded 8.0 mg 2-(Ethyl-{5-[1-(4-ethyl-phenyl)-1H-indol-5-yl]-pentyl}-amino)-ethanol as colorless oil, MS: 379 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503907B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-a59a4b9063ea42ea9a284ed235f8f68e |
| Source note | uspto-grants-2003_01 |