Potassium Carbonate → (6-Bromo-hexyloxy)-1-(4-fluoro-phenyl)-2,3-dihydro-1H-indole

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Reaction Conditions

Reaction Steps

460 mg (2 mmol) 1-(4-Fluoro-phenyl)-2,3-dihydro-1H-indol-5-ol in 6 ml acetone were treated with 830 mg (6 mmol) powdered K2CO3 and 1 ml (6 mmol) 1,6-dibromohexane. The suspension was stirred at 60° C. for 6 h, cooled to RT, diluted with acetone, filtered and concentrated. Column chromatography on silica gel with a gradient hexane to hexane/EtOAc 19:1 yielded 210 mg (25%) (6-Bromo-hexyloxy)-1-(4-fluoro-phenyl)-2,3-dihydro-1H-indole as yellow oil, MS: 392(MH+, 1Br).

Provenance & Evidence