4-Pentyn-1-ol → HCID 69548656, compound

HRID 1633687Notes

Reaction equation

HRID 1633687 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13](Br)=[CH:14][CH:15]=2)[C:10]([CH3:18])=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:19]([OH:24])[CH2:20][CH2:21][C:22]#[CH:23]>>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:23]#[C:22][CH2:21][CH2:20][CH2:19][OH:24])=[CH:14][CH:15]=2)[C:10]([CH3:18])=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 793464-Pentyn-1-olHCID 69548185HCID 69548185, compound

Product 1

HCID 69548656HCID 69548656, compound

Procedure

In analogy to example 7.2, 5-Bromo-3-methyl-indole-1-carboxylic acid tert-butyl ester and 4-pentynol were converted to yield 5-(5-Hydroxy-pent-1-ynyl)-3-methyl-indole-1-carboxylic acid tert-butyl ester as brown gum, MS: 313 (M).

Sources & evidence

ORD record
ord-4a2f6ec8182d4770bea59866813fb62a
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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