Benzene, 1-iodo-4-(trifluoromethyl)- → HCID 10272984, compound

HRID 1633690Notes

Reaction equation

[CH2:1]([N:4]([CH3:20])[CH2:5][CH2:6][CH2:7][C:8]#[C:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][CH:14]=[C:13]2[CH3:19])[CH:2]=[CH2:3].I[C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=1>>[CH2:1]([N:4]([CH3:20])[CH2:5][CH2:6][CH2:7][C:8]#[C:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[N:15]([C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=1)[CH:14]=[C:13]2[CH3:19])[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-

HCID 18679478HCID 18679478, compound

Product 1

HCID 10272984HCID 10272984, compound

Procedure

In analogy to example 17.1, Allyl-methyl-[5-(3-methyl-1H-indol-5-yl)-pent-4-ynyl]-amine and 1-Iodo-4-trifluoromethyl-benzene were converted to yield Allyl-methyl-{5-[3-methyl-1-(4-trifluoromethyl-phenyl)-1H-indol-5-yl]-pent-4-ynyl}-amine as yellow oil, MS: 411 (MH+).

Sources & evidence

ORD record: ord-fab1bde3596f41e3904ff911184889df
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06503907B2

Reaction notes

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