Benzene, 1-fluoro-4-(trifluoromethyl)- → HCID 18679480, compound

HRID 1633693Notes

Reaction equation

[CH2:1]([N:4]([CH3:20])[CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]([CH3:19])=[CH:13]2)[CH:2]=[CH2:3].F[C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=1>>[CH2:1]([N:4]([CH3:20])[CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[N:15]([C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=1)[C:14]([CH3:19])=[CH:13]2)[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-

HCID 18679526HCID 18679526, compound

Product 1

HCID 18679480HCID 18679480, compound

Procedure

In analogy to example 9.1, Allyl-methyl-[4-(2-methyl-1H-indol-5-yloxy)-butyl]-amine and 1-Fluoro-4-trifluoromethyl-benzene were converted to yield Allyl-methyl-{4-[2-methyl-1-(4-trifluoromethyl-phenyl)-1H-indol-5-yloxy]-butyl}-amine as yellow viscous oil, MS: 417 (MH+).

Sources & evidence

ORD record: ord-5b5765c05aae45fea96ad8de106adc3b
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06503907B2

Reaction notes

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