Benzene, 1-fluoro-4-(trifluoromethyl)- → HCID 18679559, compound

HRID 1633695Notes

Reaction equation

[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15]([CH3:20])=[C:14]2[CH3:21])[CH3:5])[CH:2]=[CH2:3].F[C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=1>>[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[N:16]([C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=1)[C:15]([CH3:20])=[C:14]2[CH3:21])[CH3:5])[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-

HCID 18679574HCID 18679574, compound

Product 1

HCID 18679559HCID 18679559, compound

Procedure

In analogy to example 9.1, Allyl-[4-(2,3-dimethyl-1H-indol-5-yloxy)-butyl]-methyl-amine and 1-Fluoro-4-trifluoromethyl-benzene were converted to yield Allyl-{4-[2,3-dimethyl -1-(4-trifluoromethyl-phenyl)-1H-indol-5-yloxy]-butyl}-methyl-amine as yellow oil, MS: 431 (MH+).

Sources & evidence

ORD record: ord-dbcda5bfa53e4949bb3235e48749b126
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06503907B2

Reaction notes

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