HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(1,1-Dimethyl-prop-2-ynyl)-methyl-amino]-ethanol → 2-({3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-1,1-dimethyl-prop-2-ynyl}-methyl-amino)-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(1,1-Dimethyl-prop-2-ynyl)-methyl-amino]-ethanol | HCID 18679531 | — |
| Reactant | Trifluoro-methanesulfonic acid 1-(4-fluoro-phenyl)-1H-indol-5-yl ester | HCID 86585583 | — |
| Product | 2-({3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-1,1-dimethyl-prop-2-ynyl}-methyl-amino)-ethanol | HCID 18679433 | — |
Reaction Steps
In analogy to example 17.3, Trifluoro-methanesulfonic acid 1-(4-fluoro-phenyl)-1H-indol-5-yl ester and 2-[(1,1-Dimethyl-prop-2-ynyl)-methyl-amino]-ethanol were converted to yield 2-({3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-1,1-dimethyl-prop-2-ynyl}-methyl-amino)-ethanol as orange viscous oil, MS: 351 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503907B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-e699eae05cdc4e33a7b8bd6c3b1ce572 |
| Source note | uspto-grants-2003_01 |