反应详情

6,7,8,9-Tetrahydro-5H-benzo[a]cyclohepten-5-one (18.5 g, 11.5 mmol) was mechanically stirred at −15° C. and treated with concentrated sulfuric acid (41 mL) over 5 minutes, stirred 10 minutes, treated dropwise over 10 minutes with a mixture of fuming nitric acid (9 mL) and concentrated sulfuric acid (14 mL), stirred at −15° C. for 15 minutes and poured carefully onto a mixture of ice (200 g) and water (200 mL). The resulting solid was collected by filtration, washed with water (100 mL, 2×), dried and recrystallized from ethanol (200 mL). The resulting solid was removed by filtration and the filtrate was suspended on silica gel and purified on silica gel eluting with ethyl acetate:hexanes 12:88 to provide the desired product.

1. stirringstirred at −15° C. for 15 minutes
2. filtrationThe resulting solid was collected by filtration
3. washwashed with water (100 mL, 2×)
4. customdried
5. customrecrystallized from ethanol (200 mL)
6. customThe resulting solid was removed by filtration
7. custompurified on silica gel eluting with ethyl acetate:hexanes 12:88