HCID 11459960, compound → HCID 18624494, compound

Participants

Reaction Steps

A suspension of 5-fluoro-4-[3-oxo-3-(1H-pyrrol-2-yl)-propyl]-1,3-dihydro-indol-2-one (from Example 5 above) (50 mg, 0.184 mmol) in 1.0 N NaOH (10 mL) was heated under reflux overnight. The reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (3×50 mL). The combined organic extracts were successively washed with water (10 mL) and brine (10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to give 6-fluoro-3-(1H-pyrrol-2-yl)-4,5-dihydro-1H-benzo[cd]indol-2-one as a yellow solid. (Yield 42.2 mg, 90.4%).

Provenance & Evidence