Methanesulfonic Acid → 5-(2-amino-ethoxy)-6-fluoro-3-(1H-pyrrol-2-yl)-1H-benzo[cd]indol-2-one methanesulfonic acid salt

Participants

Reaction Steps

5-(2-Amino-ethoxy)-6-fluoro-3-(1H-pyrrol-2-yl)-1H-benzo[cd]indol-2-one (from Example 19 above) (62.3 mg, 0.20 mmol) was dissolved in hot 1,4-dioxane (2.5 mL) and the solution was filtered through a glass filter. To the clear filtrate was added dropwise a solution of methanesulfonic acid (Aldrich, 16.0 mg, 0.16 mmol) in 1,4-dioxane (0.2 mL) at room temperature and the mixture was stirred for 10 minutes. The precipitate formed was collected and washed with 1,4-dioxane, ether and dried in vacuo to afford 5-(2-amino-ethoxy)-6-fluoro-3-(1H-pyrrol-2-yl)-1H-benzo[cd]indol-2-one methanesulfonic acid salt as a yellow solid. (Yield 52.5 mg, 64.5%).

Provenance & Evidence