Hydrochloric Acid → HCID 9947168, compound

Participants

Reaction Steps

A solution of 5-(2-amino-ethylsulfanyl)-6-fluoro-3-(1H-pyrrol-2-yl)-1H-benzo[cd]indol-2-one (from Example 40 above) (20 mg, 0.06 mmol) in DMF (2.5 mL) was treated with aqueous HCl with vigorous stirring. The solution was lyophilized and the residue was dissolved in methanol, filtered and concentrated. The residue was further purified by precipitation out of methanol/CH2Cl2 (1:3) with excess pentane to give 5-(2-amino-ethylsulfanyl)-6-fluoro-3-(1H-pyrrol-2-yl)-1H-benzo[cd]indol-2-one hydrochloride salt as a dark yellow solid. (Yield 17 mg, 76%).

Provenance & Evidence