反应详情

450 ml of toluene, 45 g (0.44 mole) of concentrated sulfuric acid and 45 ml of glacial acetic acid were added to 126.7 g (0.45 mole) of 2-(4-chlorophenyl)-N-(1-cyano-1,2-dimethylpropyl)propanamide. The mixture was refluxed for 4 hours with heating, to give rise to a reaction. After the completion of the reaction, the reaction mixture was cooled and dropwise added to a solution of 18.2 g (0.45 moles) of sodium hydroxide dissolved in 300 ml of water. The organic layer was separated, then washed with a saturated aqueous sodium bicarbonate solution and water, and concentrated to obtain 125 g (0.448 mole) of 2-[1-(4-chlorophenyl)ethyl]-4-isopropyl-4-methyl-1,3-oxazol-5-one (yield=99.6%).

1. temperatureThe mixture was refluxed for 4 hours
2. temperaturewith heating
3. customto give rise
4. customto a reaction
5. customAfter the completion of the reaction
6. temperaturethe reaction mixture was cooled
7. customThe organic layer was separated
8. washwashed with a saturated aqueous sodium bicarbonate solution and water
9. concentrationconcentrated