Sulfuric Acid → 2-(4-chlorophenyl)-N-[1-methyl-1-isopropyl-2-oxopropyl]propanamide

Participants

Reaction Conditions

Reaction Steps

In a reactor were placed 57.5 g (0.156 mole) of 4-[2-(4-chlorophenyl)propanoylamino]-4,5-dimethyl-3-oxohexanoate, 156 ml of 2-propanol, 62.4 ml of water and 15.6 ml of concentrated sulfuric acid. The mixture was refluxed for 7 hours with heating, to give rise to a reaction. After the completion of the reaction, the reaction mixture was cooled to 60° C. 446 ml of water was added for further cooling. The mixture was neutralized with a 23% aqueous sodium hydroxide solution. The precipitated crystals were collected by filtration to obtain 41.5 g (0.14 mole) of 2-(4-chlorophenyl)-N-[1-methyl-1-(methylethyl)-2-oxopropyl]propanamide (yield=90%).

Provenance & Evidence