Sulfuric Acid → HCID 18680189, compound

Participants

Reaction Steps

In a reactor were placed 2.5 g (0.007 mole) of 4-[(4-chlorophenyl)acetylamino]-4,5-dimethyl-3-oxohexanoate, 7 ml of 2-propanol, 8 ml of water and 0.7 ml of concentrated sulfuric acid. The mixture was refluxed for 5 hours with heating, to give rise to a reaction. After the completion of the reaction, the reaction mixture was cooled at room temperature. 20 ml of water was added. The mixture was neutralized with a 23% aqueous sodium hydroxide solution. The precipitated crystals were collected by filtration to obtain 2.37 g (0.0067 mole) of N-[1-methyl-1-(methylethyl)-2-oxopropyl]-(4-chlorophenyl)acetamide (yield=96.3%).

Provenance & Evidence