Water → HCID 9922328, compound

Participants

Reaction Steps

27.1 g of acetamidomalonic acid diethyl ester are heated for 14 hours with 19.6 g of 5-bromo-2-methyl-2-pentene and 16.6 g of potassium carbonate in 100 ml of MIBK in a water separator. The reaction solution was extracted with 100 ml of water, and the organic phase was concentrated in vacuo. LC-MS analysis of the residue shows that it is a mixture of N-acetyl-D,L-2-amino-6-methyl-5-heptenoic acid ethyl ester (M+H+=228) and acetamido-(4-methyl-3-pentenyl)-malonic acid diethyl ester (M+H+=300) in a ratio of 3:2.

Provenance & Evidence