HCID 86758778, compound → HCID 86758780, compound

Participants

Reaction Steps

A suspension of a mixture of ethyl (1SR,2SR,3RS)-2-hydroxymethyl-3-vinylcyclopropane carboxylate (500 mg, 2.94 mmol) and 5% palladium on carbon (70-mg) in methanol (25 mL) was stirred under hydrogen atmosphere overnight. The catalyst was then filtered off through celite and the solvent was removed under vacuo. The residue was purified by column chromatography using ethyl acetate and hexane 1:2 as eluent to give 380 mg (80% yield) of ethyl (1SR,2SR,3RS)-3-ethyl-2-hydroxymethylcyclopropane carboxylate.

Provenance & Evidence