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HRID1633846

反应详情

EQUATION

反应方程式

HRID 1633846 的结构方程式

REACTANTS

反应物

5
结构：O
HCID962

Water

H2O

结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：O=C(N[C@H](CO)C(=O)O)OCc1ccccc1
HCID489184

未命名化合物

结构：CNCc1cc(C(=O)OC(C)(C)C)ccc1F
HCID11791275

1,1-Dimethylethyl 4-fluoro-3-[(methylamino)methyl]benzoate

C13H18FNO2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)c1ccc(F)c(CNCC(=O)[C@@H](CO)NC(=O)OCc2ccccc2)c1
HCID131723730

未命名化合物

收率 85.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O.ClCCl
溶剂HCID22350042

未命名化合物

PROCEDURE

实验过程

According to the procedure of Preparation 4(c), except using tert-butyl 4-fluoro-3-(methylaminomethyl)benzoate (4.00 g, 16.7 mmole), N-(benzyloxycarbonyl)-D-serine (4.00 g, 16.7 mmole), HOBt.H2O (2.3 g, 17 mmole), DCC (2.4 g, 11.6 mmole), and 1:1 DMF/CH2Cl2 (100 mL), the title compound (6.60 g, 79%) was prepared as a sticky foam following flash chromatography on silica gel (50% EtOAc/hexanes): MS (ES) m/e 461.1 (M+H)+.