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HRID1633847

反应详情

EQUATION

反应方程式

HRID 1633847 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：O=C(O)CNC(=O)OCc1ccccc1
HCID14349

Glycine, N-[(phenylmethoxy)carbonyl]-

C10H11NO4

结构：O.On1nnc2ccccc21
HCID2796029

1H-Benzotriazol-1-ol--water (1/1)

C6H7N3O2

结构：CNCc1cc(C(=O)OC(C)(C)C)ccc1F
HCID11791275

1,1-Dimethylethyl 4-fluoro-3-[(methylamino)methyl]benzoate

C13H18FNO2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)c1ccc(F)c(CNCC(=O)CNC(=O)OCc2ccccc2)c1
HCID57047363

未命名化合物

收率 101%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O.ClCCl
溶剂HCID22350042

未命名化合物

PROCEDURE

实验过程

According to the procedure of Preparation 4(c), except using tert-butyl 4-fluoro-3-(methylaminomethyl)benzoate (4.00 g, 16.7 mmole), N-(benzyloxycarbonyl)glycine (3.50 g, 16.7 mmole), HOBt H2O (2.3 g, 17 mmole), DCC (2.4 g, 11.6 mmole), and 1:1 DMF/CH2Cl2 (100 mL), the title compound (7.26 g, 100%) was prepared as a thick yellow oil following flash chromatography on silica gel (30% EtOAc/hexanes): MS (ES) m/e 431.02 (M+H)+.