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Triethylamine → HCID 86588818、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Z-D-Ser-OH | HCID 489184 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 反応物 | HCID 23505584 | HCID 23505584 | — |
| 溶媒 | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| 生成物 | HCID 86588818 | HCID 86588818 | 19.4% |
反応手順
According to the procedure of Preparation 4(c), except using tert-butyl 4-fluoro-3-(benzylaminomethyl)benzoate (4.80 g, 15.2 mmole), N-(benzyloxycarbonyl)-D-serine (3.83 g, 16 mmole), HOBt H2O (2.16 g, 16 mmole), Et3N (2.24 mL, 16 mmole), EDC.HCl (3.07 g, 16 mmole), and 1:1 DMF/CH2Cl2 (75 mL), the title compound (1.58 g, 19%) was prepared as a thick oil following flash chromatography on silica gel (40% EtOAc/hexanes): 1H NMR (300 MHz, DMSO-d6) mixture of amide rotamers δ 7.39-8.18 (m, 2 H), 7.18-7.37 (m, 11 H), 4.25-5.11 (m, 7 H), 3.33-4.04 (m, 2 H), 1.53 (s, 9 H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06503903B1 |
| 出典データセット | uspto-grants-2003_01 |
| ORD ID | ord-5062e63d83574e94b1a5f13128e2cc8b |
| 出典メモ | uspto-grants-2003_01 |