反应详情

温度

70 °C

A solution of dimethyl 2,6-naphthalenedicarboxylate (39.6 g, 162 mmol) in dioxane (1.2 L) was heated to 70-80° C., slowly treated with a solution of KOH (9.1 g, 162 mmol) in methanol (162 mL), heated to 70° C., stirred for 30 minutes, cooled to room temperature, and filtered. The solid was washed sequentially with dioxane and diethyl ether, dissolved in water, adjusted to pH<7 with 1M HCl, and filtered. The solid was washed with water and dried to provide the desired product.

1. temperaturecooled to room temperature
2. filtrationfiltered
3. washThe solid was washed sequentially with dioxane and diethyl ether
4. dissolutiondissolved in water
5. filtrationfiltered
6. washThe solid was washed with water
7. customdried