Sodium Hydroxide → HCID 11275999, compound

Participants

Reaction Steps

A solution of Example 13F (0.73 g, 4.2 mmol) in concentrated H2SO4 (7.5 mL) at 0° C. was treated with KNO3 (0.47 g, 4.6 mmol), stirred for 30 minutes, treated with ice water, adjusted to pH>7 with 25% NaOH, and extracted with dichloromethane. The combined extracts were washed with H2O and brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 30% ethyl acetatehexanes to provide the desired product.

Provenance & Evidence