HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1633885Generated: October 26, 2026
Acetic Acid → 3-{4-[(4-propylcyclohexylamino)methyl]benzoylamino}propionic Acid
https://huagongshe.com/reaction/1633885
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 4-Propylcyclohexanone | HCID 142482 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(4-Aminomethylbenzoylamino)propionic acid | HCID 22502120 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 3-{4-[(4-propylcyclohexylamino)methyl]benzoylamino}propionic Acid | HCID 22502088 | — |
Reaction Steps
The resulting resin bound 3-(4-aminomethylbenzoylamino)propionic acid was treated with 98 mg 4-propylcyclohexanone (700 μmol) dissolved in 500 μL 1,2-dichloroethane, 50 μL acetic acid and a slurry of 148 mg NaBH(OAc)3 (700 μmol) in 1 mL 1,2-dichloroethane. Over night shaking at 25° C. followed by filtration and washing with 2×1 mL dichloromethane, 2×1 mL CH3OH:DMF 1:1 and 3×1 mL DMF afforded resin bound 3-{4-[(4-propylcyclohexylamino)-methyl]benzoylamino}propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06503949B1 |
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| Source dataset | uspto-grants-2003_01 |
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| ORD ID | ord-b55b2ab7bddf4ce68af9fc3aeec264c3 |
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| Source note | uspto-grants-2003_01 |
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