Ethanol → HCID 68904861, compound

Participants

Reaction Steps

180 mg LiOH dissolved in 2.2 mL H2O was added to the entire yield of the above 3-{4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester dissolved in 22 mL abs. EtOH. After 1 hour at 25° C. the solvent was evaporated and 10 mL H2O followed by 500 mg citric acid dissolved in 20 mL H2O was added to the residue affording a pH of 4-5. The resulting product was a mixture of the acid and its lithium salt.

Provenance & Evidence