Aniline → 5-Methylsulfonyl-2-methylphenyl isocyanate

HRID 1633923Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH3:14])=[C:9]([N+:11]([O-])=O)[CH:10]=1)(=[O:4])=[O:3].NC1C=CC=CC=1.[N-]=[C:23]=[O:24]>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH3:14])=[C:9]([N:11]=[C:23]=[O:24])[CH:10]=1)(=[O:4])=[O:3]

Participants

Reactant 3

HCID 6115Aniline

HCID 105034Isocyanate

HCID 6871254-Mesyl-2-nitrotoluene

Product 1

HCID 225019075-Methylsulfonyl-2-methylphenyl isocyanate

Procedure

5-Methylsulfonyl-2-methylphenyl isocyanate was prepared from the corresponding 5-methylsulfonyl-2-methyl-1-nitrobenzene via reduction to the corresponding aniline followed by conversion to the isocyanate as described previously.

Sources & evidence

ORD record: ord-79965b8a3c6645aab8b7e4b34c6b3e68
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06503949B1

Reaction notes

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