反应详情

A mixture of 5-nitro-2-trifluoromethoxybenzoic acid (6.43 g, 25.6 mmol) and 128 mg of 10% Pd/C in 10 mL of absolute ethanol was stirred in a hydrogen atmosphere overnight at room temperature. The catalyst was filtered off and the filtrate was evaporated to dryness. The re-residue was triturated with diethyl ether and the crystals were filtered off and dried to afford 1.644 g (29%) of 5-amino-2-trifluoromethoxybenzoic acid.

1. filtrationThe catalyst was filtered off
2. customthe filtrate was evaporated to dryness
3. customThe re-residue was triturated with diethyl ether
4. filtrationthe crystals were filtered off
5. customdried