HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1633974Generated: October 26, 2026
Methylamine → N-methyl-3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]-ureido}benzamide
https://huagongshe.com/reaction/1633974
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid pentafluorophenyl ester | HCID 18346946 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-methyl-3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]-ureido}benzamide | HCID 22502052 | — |
Reaction Steps
To the above resin bound 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl) benzyl]-ureido}benzoic acid pentafluorophenyl ester was added a solution of methylamine in THF (2M, 5 mL). The mixture was shaken at 25° C. overnight, filtered and washed with THF (2×10 mL), affording the resin bound title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06503949B1 |
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| Source dataset | uspto-grants-2003_01 |
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| ORD ID | ord-6ccf41525c624ebeba20dfbadb67cea3 |
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| Source note | uspto-grants-2003_01 |
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