HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Benzo[b]thiophene-2-carbonyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Benzo(b)thiophene-2-carboxylic acid | HCID 95864 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Benzo[b]thiophene-2-carbonyl Chloride | HCID 142384 | — |
Reaction Steps
The Benzo[b]thiophene-2-carbonyl chloride was prepared by adding toluene (2 mL), DMF (2 drops) and thionyl chloride (50 μL) to benzo[b]thiophene-2-carboxylic acid. Heating the mixture to reflux for 5 hours followed by removal of the solvent afforded the crude product, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503949B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-b190a0fa2a264adbba9ccf5bb8506825 |
| Source note | uspto-grants-2003_01 |