Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 22501866 | HCID 22501866 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 4017380 | HCID 4017380 | 70% |
Reaction Steps
4-Nitroisophthalimide (25.0 g, 130.0 mmol) was dissolved in DMF (250 mL). Isopropyl bromide (61.0 mL, 650 mmol) and potassium carbonate (36.0 g, 260 mmol) were added and the mixture was heated to 60° C. overnight. Water (1.0 L) was added, and the precipitate formed was collected by filtration, washed twice with water and dried overnight in a vacuum oven to afford 21.3 g (70%) of pure N-isopropyl-4-nitrophthalimide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06503949B1 |
|---|
| Source dataset | uspto-grants-2003_01 |
|---|
| ORD ID | ord-df4a3551cc964fcbb1785f509e366dea |
|---|
| Source note | uspto-grants-2003_01 |
|---|
