Morpholine → HCID 12050572, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-Chloropropyl)-2-(3-fluorophenyl)-thiazolidin-4-one (1.15 mm, 0.315 g) and morpholine (1.15 mm, 0.1 g) are mixed in 20 mL DMF in the presence of N,N-diisopropylethylamine (1.15 mm, 0.2 mL) and a catalytic amount of KI. The mixture is heated at 60° C. for 24 hours, then 20 mL of EtOAc is added to the mixture. The organic layer is washed with brine and dried. The solvent is evaporated, and the residue is triturated with hexane, 0.31 g of the product is isolated (84%).

Provenance & Evidence