3-Chlorobenzaldehyde → HCID 86758785, compound

Participants

Reaction Conditions

Reaction Steps

2-( 3-Chlorophenyl)-3-(3-piperidin-1-ylpropyl)-thiazolidin-4-one (3 mm, 1 g), 3-chlorobenzaldehyde (4.5 mm, 0.51 mL), and potassium t-butoxide (4.5 mm, 0.5 g) are mixed in 50 mL toluene with molecular sieves and heated at 60° C. for 4 hours. The molecular sieves are removed by filtration, and the solvent is concentrated to dryness. Pure Compound 2 (0.5 g) is isolated by column chromatography (5% MeOH/CH2Cl2). MS: m/z (APCI, AP+) 462 [M]+. MP 137-139° C.

Provenance & Evidence