Water → HCID 22314782, compound

Participants

Reaction Steps

3.5 g of pyridin-4-ylacetonitrile and then 2.6 ml of 1,2-dibromoethane are added to a mixture of 2.5 g of sodium amide in 80 ml of DCM and the mixture is left stirring overnight at RT. The reaction mixture is poured into water, extracted with AcOEt, the organic phase washed with water, dried over Na2SO4 and the solvents evaporated off under vacuum. The residue is chromatographed on silica gel, eluting with DCM and then with the DCM/MeOH mixture from (99/1; v/v) to (95/5; v/v). 2.5 g of the expected product are obtained.

Provenance & Evidence