Benzyl isocyanate → HCID 131723737, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(R,S)-{2-[7-amino-3-(S)-(2-carboxy-ethyl)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-acetylamino}-3-phenyl-propionic acid (0.15 mmol, 70 mg) in DMF (2.5 ml) was added benzylisocyanate (46 μl, 037 mmol). The mixture was shaken at 45° C. over night. Then the solution was evaporated and the crude product was purified by RP-HPLC to give 3-(R,S)-{2-[7-(3-benzyl-ureido)-3-(S)-(2-carboxy-ethyl)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-acetylamino}-3-phenyl-propionic acid (14 mg): MS (ISN) 600 (M−H)−.

Provenance & Evidence