Benzyl isocyanate → HCID 131723739, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(R,S)-{2-[7-Amino-3-(S)-(4-hydroxy-benzyl)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-acetylamino}-butyric acid (0.2 mmol, 88mg). in DMF (6 ml) was added benzylisocyanate (158 μl 1.2 mmol). The mixture was shaken at 45° C. over night and then was evaporated to dryness. The crude product was purified by RP-HPLC to give 3-(R,S)-{2-[7-(3-benzyl-ureido)-3-(S)-(4-hydroxy-benzyl)-2,5-dioxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-acetylamino}-butyric acid: MS (ISN) 572 (M−H)−.

Provenance & Evidence