Lithium Hydroxide → HCID 69999870, compound

Participants

Reaction Steps

Hydrolysis of (R,S)-3-{2-[7-(3-benzyl-ureido)-5-oxo-2-phenyl-2,3-dihydro-5H-benzo[f][1,4]oxazepin-4-yl]-acetylamino}-3-phenyl-propionic acid ethyl ester (0.15 g, 0.24 mmol) in the presence of aqueous LiOH, as described in Example 1, yielded (R,S)-3-{2-[7-(3-benzyl-ureido)-5-oxo-2-phenyl-2,3-dihydro-5H-benzo[f][1,4]oxazepin-4-yl]-acetylamino}-3-phenyl-propionic acid (0.125 g, 0.21 mmol): mp. 138-140° C.; MS (ISP) 593 (M+1)+.

Provenance & Evidence